The low value trenbolone enanthate 200 of norfloxacin binding to plasma proteins (10-15%) and high solubility in lipids are responsible for a large amount of the drug distribution and good penetration into tissues and organs (kidney parenchyma, ovaries, fluid seminiferous tubules, prostate, uterus, abdominal organs and small pelvis, bile, breast milk). It penetrates through the blood-brain barrier and the placenta. The duration of the antimicrobial effect -. About 12 h minor extent metabolized in the liver. The half-life of 3-4 hours.Excreted by the kidneys by glomerular filtration and tubular secretion. Within 24 hours from the receipt of 32% of the dose excreted by the kidneys in an unmodified form, 5-8% – in the form of metabolites in the bile is allocated about 30% of the dose.
Infectious-inflammatory diseases caused by pathogens susceptible to the drug:
- acute and chronic infections of the urinary tract (urethritis, cystitis, pyelonephritis);
- genital infections: cervicitis, endometritis, chronic bacterial prostatitis;
- uncomplicated gonorrhea;
- Bacterial gastroenteritis (salmonellosis, shigellosis);
- prevention of recurrence of urinary tract infections;
- Prevention of sepsis in patients with neutropenia;
- prevention of traveler’s diarrhea.
- Hypersensitivity to norfloxacin, components of the drug and other quinolones;
- deficiency of glucose-6-phosphate dehydrogenase;
- childhood and adolescence (18 years);
- pregnancy and lactation;
Precautions: cerebral atherosclerosis, stroke, epilepsy, epileptic syndrome, renal / hepatic insufficiency, the presence of an allergic reaction to acetylsalicylic acid.
Pregnancy and lactation Safety of use during pregnancy and lactation lactation has not been studied. Appoint during pregnancy, the drug is only “life” readings when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should stop breastfeeding.
Dosage and administration . Inside an empty stomach (at least 1 hour before or 2 hours after meals) and washed down with plenty of liquid In the absence of specific instructions, the doctor recommends the following doses: 1 tablet (400 mg) 2 times a day. The treatment duration of 7 to 14 days, longer treatment is carried out if necessary. Chronic bacterial prostatitis is assigned 400 mg 2 times a day for 4-6 weeks or longer. In uncomplicated gonorrhea drug administered a single dose of 800 – 1200 mg or 2 times a day 400 mg within 3-7 days. in bacterial gastroenteritis (shigellosis, salmonellosis) recommended 400 mg 2 times a day for up to 5 days. for the prevention of traveler’s diarrhea is recommended to take 400 mg a day for 1 day before departure , at all times during travel, and two days after the end (no more than 21 days). For the trenbolone enanthate 200 prevention of septicemia in neutropenic administered 400 mg 2 times a day to 8 weeks. in acute uncomplicated cystitis administered 400 mg 2 times a day for 3-5 days. For the prevention of recurrent uncomplicated urinary tract infections with frequent exacerbations (more than 3 episodes a year, or more than 2 within six months) drug prescribed 200 mg (1/2 nolitsin tablet) 1 time at night for a long time ( from 6 months to several years). Patients with impaired renal function at creatinine clearance 20 mL / min correction dosing regime is not required. When creatinine clearance less than 20 ml / min (serum creatinine level or above 5 mg / 100ml) and patients buy trenbolone on hemodialysis, appoint half the therapeutic dose nolitsin 2 times a day or a full dose 1 time per day.
From the digestive system: loss of appetite, bitter taste in the mouth, nausea, vomiting, abdominal pain, diarrhea, pseudomembranous enterocolitis (with prolonged use), increased activity of “liver” transaminases.
From the urinary system: crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, urethral bleeding, increase in urea and plasma creatinine.
From the nervous system: headache, dizziness, fainting, insomnia, hallucinations. Elderly patients may be: fatigue, drowsiness, restlessness, irritability, anxiety, depression, tinnitus.
Cardio-vascular system: tachycardia, arrhythmias, lowering blood pressure, vasculitis.
Allergic reactions: rash, itching, hives, swelling, malignant exudative erythema (Stevens-Johnson syndrome).
From the musculoskeletal system: arthralgia, tendinitis, tendon rupture (usually in the case of combination with contributing factors).
From the hematopoietic system: eosinophilia, leukopenia, decreased hematocrit.
Overdose In case of overdose, you may experience the following symptoms: nausea, vomiting, diarrhea. In severe cases, dizziness, drowsiness, “cold” sweat, convulsions, puffy face without major changes in hemodynamic readings. Treatment: gastric lavage, adequate hydration therapy with forced diuresis and symptomatic therapy. It requires inspection and observation in a hospital for a few days. No specific antidote.
Interaction with other drugs:
With simultaneous use of norfloxacin and theophylline should monitor the concentration of theophylline in the plasma and adjust the dose, as norfloxacin reduce theophylline clearance to 25%, and may be a corresponding development of unwanted side effects. Reduces the effect of nitrofurans. Norfloxacin may enhance the therapeutic effect of cyclosporine and warfarin, in some cases, the use of cyclosporine with norfloxacin was observed increase in serum creatinine concentration, so in these patients is necessary to monitor this indicator.
The simultaneous use of norfloxacin and antacids containing aluminum or magnesium hydroxide, and preparations containing iron, zinc, sucralfate, reduces absorption norfloxacin (reception interval between them should be not less trenbolone enanthate 200 than 2 hours).
Concomitant use with drugs that reduce the seizure threshold, may lead to the development of epileptiform seizures. The simultaneous use of corticosteroids may increase the risk of tendinitis and tendon rupture cases. Norfloxacin may enhance the therapeutic effect of hypoglycemic agents (sulfonylureas). Simultaneous treatment with norfloxacin drugs have the potential ability to lower blood pressure, it can cause a sharp decline. Therefore, in such cases, as well as simultaneous administration with barbiturates and other drugs for general anesthesia should monitor heart rate, blood pressure and ECG.
Cautions During treatment norfloxacin patients should receive a sufficient amount of fluid (under the control of urine output). During therapy may increase the prothrombin index (during surgery should monitor the status of the blood coagulation system). During treatment with norfloxacin should avoid exposure to direct sunlight. When the appearance of pain in the tendons or the need to stop the drug at the first sign of tenosynovitis. During therapy norfloxacin recommended to avoid excessive physical exertion. If you have an allergic reaction to acetylsalicylic acid azo dye E software (dye Disperse Yellow E 110) may cause hypersensitivity reactions up to bronchospasm. steroiden kaufen
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